IgM / Ag Complexes Induced by IgG / Ag and IgE / Ag , But Not Complement Receptors 1 and 2 Can Be Antibody Production in Mice Deficient for Molina and Birgitta

IgM / Ag Complexes Induced by IgG / Ag and IgE / Ag , But Not Complement Receptors 1 and 2 Can Be Antibody Production in Mice Deficient for Molina and Birgitta Heyman

Antibody production in mice deficient for complement receptors 1 and 2 can be induced by IgG/Ag and IgE/Ag, but not IgM/Ag complexes.

Deficiencies in C factors C2, C3, or C4 as well as lack of C receptors 1 and 2 (CR1/2) lead to impaired Ab production. Classical pathway activation plays a major role, as mice deficient in factor B, a key factor in the alternative pathway, have normal Ab production. Abs in complex with their specific Ag are known to feedback regulate the Ab response, and enhanced responses are initiated by IgM,...

Marginal zone B cells transport IgG3-immune complexes to splenic follicles.

Ag administered together with specific IgG3 induces a higher Ab response than Ag administered alone, an effect requiring the presence of complement receptors 1 and 2 (CR1/2). In this study, we have investigated the fate of Ag, the development of germinal centers (GCs), and the Ab response after i.v. administration of IgG3 anti-trinitrophenyl (TNP) in complex with OVA-TNP. After 2 h, OVA-TNP was...

Feedback Enhancement of Antibody Responses via Complement and Fc Receptors

Dahlström, J. 2001. Feedback Enhancement of Antibody Responses via Complement and Fc Receptors. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1000. 53 pp. Uppsala. ISBN 91-554-4943-3. IgG, IgM and IgE in complex with antigen have the capacity to regulate specific immune responses. In this investigation, the role of Fc receptors for...

Modulation of the humoral immune response by antibody-mediated antigen targeting to complement receptors and Fc receptors.

During an ongoing immune response, immune complexes, composed of Ag, complement factors, and Igs, are formed that can interact with complement receptors (CRs) and IgG Fc receptors (Fc gamma R). The role of CR1/2 and Fc gamma R in the regulation of the immune response was investigated using OVA that was chemically conjugated to whole IgG of the rat anti-mouse CR1/2 mAb 7G6. FACS analysis using t...